AICAR transformylase domain <p>This domain is found in the enzyme 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase <db_xref db="EC" dbkey="2.1.2.3"/> (AICARFT). AICARFT can be part of a bifunctional enzyme catalysing the last two steps in <i>de novo</i> purine biosynthesis and having also an IMP (Inosine monophosphate) cyclohydrolase <db_xref db="EC" dbkey="3.5.4.10"/> (IMPCHase) functional domain. The bifunctional enzyme forms an intertwined dimer where each monomer is composed of two separate functional domains.</p><p>This entry represents a duplicated domain in AICARFT consisting of a three layer alpha-beta-alpha sandwich [<cite idref="PUB00025174"/>]. </p>